关键词: 绝经, 干眼, 绝经激素治疗

Abstract: Dry eye is a multifactorial ocular surface disease that causes ocular pain, discomfort and vision loss, which seriously affects the quality of life of patients.Female is an important risk factor for dry eye, especially menopausal and postmenopausal women, suggesting that changes in level of sex hormone play an important role in the pathogenesis of dry eye. Sex hormones (estrogen, progesterone and androgen) affect the production of all components of tear, including water, lipids and mucins.Various mechanisms such as reduced level of sex hormone, altered feedback mechanisms, and changes in receptor receptivity interact to alter ocular surface homeostasis, resulting in dry eye. Several studies have shown the potential role of menopausal hormone therapy in dry eye among the menopausal and postmenopausal women. (Int Rev Ophthalmol, 2023, 47: 58-61)

Key words: menopause, dry eye, menopause hormone therapy